When people hear the term ketamine infusion, it can mean very different things.

Some picture a hospital setting with IV lines. Others imagine something experimental or intense. In reality, ketamine infusion therapy is a medically supervised treatment delivered in a controlled, therapeutic environment.

Let’s break down what it actually means, how it’s administered, and how it fits within a structured program like the Odyssey Method.

What Is a Ketamine Infusion?

A ketamine infusion refers to the medical administration of ketamine at a controlled dose for therapeutic purposes.

It is:

• Medically supervised
• Carefully dosed
• Delivered in a clinical setting
• Part of a structured treatment plan

In Canada, ketamine infusion therapy is regulated and provided under strict medical oversight. It is not a casual or at-home treatment.

The word “infusion” is often associated with intravenous delivery, but there are actually two primary medical routes used in clinical settings.

How Ketamine Is Administered: IV vs IM

1. Intravenous (IV) Ketamine

An intravenous ketamine infusion involves placing a small IV line into a vein, typically in the arm or hand.

How it works:

• The IV remains in place for the duration of treatment
• The dose can be slowly titrated, meaning it is gradually increased
• Onset is smoother and more controlled

Some providers prefer IV because it allows fine adjustments during the session.

However, the IV line remains in place throughout treatment, which some patients find uncomfortable.

2. Intramuscular (IM) Ketamine

Intramuscular ketamine involves a single injection into a muscle, typically the glute or deltoid.

How it works:

• One injection delivers the full dose
• Onset typically begins within 2 to 5 minutes
• The experience unfolds more rapidly

Many patients prefer intramuscular ketamine because there is no IV line left in place. It is often described as a “one and done” approach.

In terms of effectiveness, the bioavailability is very similar:

• Intramuscular: approximately 98%
• Intravenous: approximately 99%

Clinically, both methods deliver highly effective absorption of the medication.

Why Some Clinics Choose IV and Others IM

The main difference comes down to pacing.

With IV ketamine infusion therapy:

• The dose can be gradually built up
• The onset feels more gradual
• There is greater ability to adjust mid-session

With intramuscular ketamine:

• The onset is faster
• The experience is more immediate
• Once administered, it unfolds naturally

Neither method is universally “better.” The right choice depends on clinical guidelines, provider expertise, and patient comfort.

The Odyssey Method: Beyond the Infusion

A ketamine infusion is just one part of a larger therapeutic process.

Within the Odyssey Method, treatment follows a structured approach:

1. Comprehensive Screening

Every client completes:

• Mental health screening
• Physical health screening

This ensures safety and suitability before any treatment begins.

2. Preparation Therapy

Before a ketamine infusion, clients work with a certified therapist to:

• Set intentions
• Understand the process
• Prepare emotionally and psychologically

Educational tools and nervous system regulation practices such as breathwork and meditation are often incorporated.

Preparation significantly impacts outcomes.

3. In-Clinic Ketamine Infusion

Treatment takes place in a medically supervised, comfortable environment.

• Sessions typically last about two hours
• The intramuscular experience lasts roughly 60 to 90 minutes
• Clients are monitored throughout

This is not a rushed medical procedure. It is intentionally structured and supported.

4. Integration Therapy

After the ketamine infusion therapy session, integration is essential.

Clients return to therapy to:

• Process insights
• Discuss emotional material
• Translate experiences into behavioral or thought pattern change

Without integration, insights can fade. With integration, they can become meaningful life shifts.

Safety and Medical Oversight

When delivered in a regulated clinical setting with proper screening, ketamine infusion therapy is considered safe for appropriate candidates.

Key safety components include:

• Medical oversight
• Clear dosing protocols
• Pre-treatment screening
• Ongoing monitoring

It is not appropriate for everyone, which is why intake screening is critical.

Who Is a Good Candidate for Treatment?

A ketamine infusion is not just a medical procedure.

When delivered as part of a structured program like the Odyssey Method, it becomes one component of a broader therapeutic journey that includes screening, preparation, supervision, and integration.

Understanding the differences between IV and intramuscular delivery helps remove confusion and empowers you to ask informed questions.

If you are exploring ketamine infusion therapy, start by speaking with a qualified medical professional to determine whether you are a safe and suitable candidate.

Explore Ketamine Infusion Therapy Safely

If you’re considering ketamine infusion therapy, the first step is a medical screening to confirm you are a safe and appropriate candidate.

Choose one option below. Our team will guide you through screening, referral requirements, and what to expect.

FAQs About Ketamine Infusion Therapy